Xtreme Everest 2

Large expedition to Everest Base Camp seeking to characterise acclimatisation to environmental hypoxia in Sherpa’s & Westerners to identify biomarkers of (mal-) adaptation that may inspire novel diagnostic/therapeutic targets for the cellular hypoxia seen in critical illness.

Responsibilities included:

• Forearm venous plethysmography
• Nitrate metabolism studies (exhaled, saliva, blood, 24hr urine)
• Ambulatory monitoring (SpO2, NIBP & ECG)
• Core physiological dataset (daily cardiorespiratory observations and symptom-scores)

Supervisors: Prof Mike Grocott & Prof Denny Levett